Comparative Genomics Analysis of the Oomycetes using the Oomycete Gene Order Browser (OGOB)

  • Oral Presentation
  • Plant Genetics and Evolution
  • 13 Jun 2018 10:00
  • FS-G01, UCD Agriculture and food science Centre
  • View all IPSAM abstracts

Jamie McGowan*
Genome Evolution Laboratory, Maynooth University

David Fitzpatrick
Genome Evolution Laboratory, Maynooth University

*Presenting Author

The oomycetes are a class of microscopic, filamentous eukaryotes within the Stramenopiles-Alveolates-Rhizaria (SAR) supergroup. They include ecologically significant animal and plant pathogens, including Phytophthora infestans, the causative agent of potato blight. Oomycetes secrete large arsenals of effector proteins that degrade host cell components, manipulate host immune responses and induce necrosis, enabling parasitic colonization. In this study, we use a range comparative genomic methods to understand how oomycete effectors and oomycete genomes have evolved to enable them to become such destructive pathogens.

Compared to other taxonomic groups, there is a lack of tools and databases to study oomycete genetics and evolution. To this end, we have developed the Oomycete Gene Order Browser (OGOB). OGOB is a curated, publicly available database for oomycete genomics that aids comparative syntenic analyses. OGOB hosts oomycete genomic data and functional annotations, as well as a number of bioinformatics tools that facilitate homology searches, multiple sequence alignments, phylogeny construction and evolutionary rates analysis. We have employed OGOB to improve oomycete gene sets, identify effectors, analyse syntenic conservation of effectors, gene duplication and clustering of genes involved in metabolic pathways. We hope that OGOB will be a useful tool for plant pathologists to study oomycete effector genes and plant resistance genes.